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The effectiveness of xanomeline/trospium chloride for the treatment of schizophrenia in adults was evaluated in two studies with identical designs. [2] Study 1 (NCT04659161) and study 2 (NCT04738123) were 5-week, randomized, double-blind, placebo-controlled, multi-center studies in adults with a diagnosis of schizophrenia according to DSM-5 ...
The variation has led to the suggestion that treatment responsive and treatment resistant schizophrenia be considered as two different subtypes. [ 149 ] [ 159 ] It is further suggested that if the subtypes could be distinguished at an early stage significant implications could follow for treatment considerations, and for research. [ 154 ]
She founded the first scientific data to suggest that patients with treatment resistant schizophrenia do not have dopaminergic abnormality, and that the majority of these patients do not respond to treatment from the initial phases of their illness. [4] She has also won a Scholarship Award for Best Article in 2022 (Editors’ Choice). [5]
The primary treatment of schizophrenia is the use of antipsychotic medications, often in combination with psychosocial interventions and social supports. [ 27 ] [ 185 ] Community support services including drop-in centers, visits by members of a community mental health team , supported employment , [ 186 ] and support groups are common.
Antipsychotic drug treatment is a key component of schizophrenia treatment recommendations by the National Institute of Health and Care Excellence (NICE), [23] the American Psychiatric Association, [24] and the British Society for Psychopharmacology. [25]
Clozapine — used in treatment-resistant schizophrenia not responsive to at least two different antipsychotics; the main reason for such restriction is agranulocytosis and other severe side effects including seizures and myocarditis. [10] Felbamate — an anticonvulsant used in refractory epilepsy.
Evenamide (INN Tooltip International Nonproprietary Name) (developmental code names NW-3509, NW-3509A) [1] is a selective voltage-gated sodium channel blocker, including (and not limited to) subtypes Na v 1.3, Na v 1.7, and Na v 1.8, which is described as an antipsychotic and is under development by Newron Pharmaceuticals as an add-on therapy for the treatment of schizophrenia.
This acts as an indicator for the onset of schizophrenia, and has potential in alerting researchers in earlier treatment. [12] Moreover, researchers oppose the tendency of researchers to attribute schizophrenia to higher-order processes like working memory, attention, and executive processing, instead choosing to inspect impairments in basic ...