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Wernicke encephalopathy (WE), also Wernicke's encephalopathy, [1] or wet brain is the presence of neurological symptoms caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B 1). [2]
Carl Wernicke discovered Wernicke encephalopathy in 1881. His first diagnosis noted symptoms including paralyzed eye movements, ataxia, and mental confusion. Also noticed were hemorrhages in the gray matter around the third and fourth ventricles and the cerebral aqueduct. Brain atrophy was only found upon post-mortem autopsy.
Korsakoff syndrome (KS) [1] is a disorder of the central nervous system characterized by amnesia, deficits in explicit memory, and confabulation.This neurological disorder is caused by a deficiency of thiamine (vitamin B 1) in the brain, and it is typically associated with and exacerbated by the prolonged, excessive ingestion of alcohol. [2]
Wernicke encephalopathy and Korsakoff syndrome are forms of dry beriberi. [6] Diagnosis is based on symptoms, low levels of thiamine in the urine, high blood lactate, and improvement with thiamine supplementation. [9] Treatment is by thiamine supplementation, either by mouth or by injection. [1] With treatment, symptoms generally resolve in a ...
Uremic encephalopathy: Arising from high levels of toxins normally cleared by the kidneys—rare where dialysis is readily available. Wernicke's encephalopathy: Arising from thiamine (B 1) deficiency, usually in the setting of alcoholism. Hashimoto's encephalopathy: Arising from an auto-immune disorder.
Encephalopathy can be caused by a number of different factors, including infections from bacteria and viruses, exposure to toxic substances, autoimmune disorders, encephalitis (inflammation of the ...
Wernicke–Korsakoff syndrome can cause brain damage and results from a Vitamin B deficiency (specifically vitamin B1, thiamine). [29] [30] This syndrome presents with two conditions, Wernicke's encephalopathy and Korsakoff psychosis. Typically Wernicke's encephalopathy precedes symptoms of Korsakoff psychosis.
Often, patients can only recognize their prodrome symptoms when they get to the pain phase and look back, Singh says. During a prodrome period, the Mayo Clinic and American Migraine Foundation say ...