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Rectal administration of medication may be performed with any of the following: A suppository, a solid drug delivery system inserted into the rectum, where it dissolves or melts to exert local or systemic effects. A micro-enema, a small amount (usually less than 10 millilitres) of a liquid-drug solution injected into the rectum.
The most common side effect seen is constipation (2–3%). Less commonly reported side effects (<0.5%) include flatulence, headache, hypophosphatemia, xerostomia (dry mouth), and bezoar formation. [24] [25] [26] Use of this drug is not recommended for people with chronic kidney failure, as it might cause aluminium accumulation and toxicity.
Common side-effects include headache, nausea, abdominal pain, and fever. [1] Serious side-effects may include pericarditis, liver problems, and kidney problems. [1] [12] Use in pregnancy and breastfeeding appears safe. [12] In people with a sulfa allergy certain formulations may result in problems. [1] Mesalazine is an aminosalicylate and anti ...
Side effects are uncommon and typically mild, [1] and may include stomach pain, abdominal cramps or diarrhea, [1] Efficacy decreases with long-term use, and may cause poor bowel function. [9] Serious allergic reactions may occur with the drug. The most severe side effect of docusate, although very rare, is rectal bleeding. [23]
[1] [5] The medication is taken by mouth or via the rectum. [1] [6] It typically begins working in around 30 minutes when given by rectum and within twelve hours when given by mouth. [3] It is a weaker laxative than bisacodyl and castor oil. [1] Common side effects of senna glycoside include abdominal cramps. [3]
Side effects associated with domperidone include dry mouth, abdominal cramps, diarrhea, nausea, rash, itching, hives, and hyperprolactinemia (the symptoms of which may include breast enlargement, galactorrhea, breast pain/tenderness, gynecomastia, hypogonadism, and menstrual irregularities).
Medications delivered to the distal one-third of the rectum at least partially avoid the "first pass effect" through the liver, which allows for greater bio-availability of many medications than that of the oral route. Rectal mucosa is highly vascularized tissue that allows for rapid and effective absorption of medications. [15]
Main side effects of oxycodone [43] Two tablets (10 mg) of oxycodone and safety blisters. The most common side effects of oxycodone include reduced sensitivity to pain, delayed gastric emptying, euphoria, anxiolysis (a reduction in anxiety), feelings of relaxation, and respiratory depression. [44]
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