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Distinct from the PANGOLIN tool, Pango lineages are regularly, manually curated based on the current globally circulating diversity. A large phylogenetic tree is constructed from an alignment containing publicly available SARS-CoV-2 genomes, and sub-clusters of sequences in this tree are manually examined and cross-referenced against epidemiological information to designate new lineages; these ...
The term variant of concern (VOC) for SARS-CoV-2, which causes COVID-19, is a category used for variants of the virus where mutations in their spike protein receptor binding domain (RBD) substantially increase binding affinity (e.g., N501Y) in RBD-hACE2 complex (genetic data), while also being linked to rapid spread in human populations ...
BA.2.86 was first reported by Denmark and Israel. [1] [11] On 18 August 2023, when only six cases had been reported from four countries (Denmark, Israel, the United Kingdom and the United States), the British healthcare authorities noted that its almost simultaneous appearance in several countries still operating detailed genomic surveillance indicated that it likely already was spreading more ...
Delta (B.617.2) First identified in India in late 2020, the delta variant soon spread across the globe. It became the dominant variant of SARS-CoV-2 until the emergence of omicron in December 2021.
On 26 November 2021, the WHO's Technical Advisory Group on SARS-CoV-2 Virus Evolution declared PANGO lineage B.1.1.529 a variant of concern and designated it with the Greek letter omicron. [10] The WHO skipped the preceding letters nu and xi in the Greek alphabet to avoid confusion with the similarities of the English word "new" and the Chinese ...
The team at PANGO behind manually curating the phylogenetic tree of SARS-CoV-2 noted the earliest sequence was from 7 December 2020. They proposed a new designation for the variant containing the mutations at the spike protein including G142D, L452R, E484Q, D614G, P681R among others and this variant went to be assigned PANGO lineage B.1.617 on ...
The Lambda variant, also known as lineage C.37, is a variant of SARS-CoV-2, the virus that causes COVID-19. [1] It was first detected in Peru in August 2020. [ 2 ] On 14 June 2021, the World Health Organization (WHO) named it Lambda variant [ 1 ] and designated it as a variant of interest . [ 3 ]
The new vaccines are still way better for the current season compared to the shot released a year ago, which targeted XBB.1.5, but the difference between what the latest vaccine is designed ...
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