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Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
655 12162 Ensembl ENSG00000101144 ENSMUSG00000008999 UniProt P18075 P23359 RefSeq (mRNA) NM_001719 NM_007557 RefSeq (protein) NP_001710 NP_001710.1 NP_031583 Location (UCSC) Chr 20: 57.17 – 57.27 Mb Chr 2: 172.71 – 172.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is ...
Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. [4] [5] BMP4 is found on chromosome 14q22-q23.BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily.
Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; it is also known as ALK-2 (activin receptor-like kinase-2). [5] ACVR1 has been linked to the 2q23-24 region of the genome. [6]
The activation of this pathway has been documented in all cellular types analyzed up to date, including hepatocytes and HCC cells. [18] [19] GDF2 also triggers Smad-2/Smad-3 phosphorylation in different endothelial cell types. [20] [21] Another pathway for GDF2 is the induced non-canonical one. Little is known about this type of pathway in GDF2.
Noggin is a signaling molecule that plays an important role in promoting somite patterning in the developing embryo. [8] It is released from the notochord and regulates bone morphogenic protein 4 (BMP4) during development. [9] The absence of BMP4 will cause the patterning of the neural tube and somites from the neural plate in the developing ...
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This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal.