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  2. IC50 - Wikipedia

    en.wikipedia.org/wiki/IC50

    Half maximal inhibitory concentration (IC 50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC 50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro , a given biological process or biological component by 50% ...

  3. Antibiotic sensitivity testing - Wikipedia

    en.wikipedia.org/wiki/Antibiotic_sensitivity_testing

    [1] [9] The results of antimicrobial susceptibility tests performed during a given time period can be compiled, usually in the form of a table, to form an antibiogram. [ 31 ] [ 32 ] Antibiograms help the clinician to select the best empiric antimicrobial therapy based on the local resistance patterns until the laboratory test results are available.

  4. European Committee on Antimicrobial Susceptibility Testing

    en.wikipedia.org/wiki/European_Committee_on...

    European Committee on Antimicrobial Susceptibility Testing (EUCAST) is a scientific committee for defining guidelines to interpret antimicrobial resistance. [1] It was formed in 1997 and is jointly organized by ESCMID , ECDC and other European laboratories.

  5. Minimum inhibitory concentration - Wikipedia

    en.wikipedia.org/wiki/Minimum_inhibitory...

    In microbiology, the minimum inhibitory concentration (MIC) is the lowest concentration of a chemical, usually a drug, which prevents visible in vitro growth of bacteria or fungi. [ 1 ] [ 2 ] MIC testing is performed in both diagnostic [ 1 ] [ 2 ] and drug discovery laboratories.

  6. Broth microdilution - Wikipedia

    en.wikipedia.org/wiki/Broth_microdilution

    Varying concentrations of the antibiotics and the bacteria to be tested are then added to the plate. The plate is then placed into a non-CO 2 incubator and incubated at thirty-seven degrees Celsius for sixteen to twenty hours. Following the allotted time, the plate is removed and checked for bacterial growth.

  7. Wortmannin - Wikipedia

    en.wikipedia.org/wiki/Wortmannin

    Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii, is a non-specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks). ). It has an in vitro inhibitory concentration (IC 50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhib

  8. Phosphodiesterase 9 inhibitor - Wikipedia

    en.wikipedia.org/wiki/Phosphodiesterase_9_inhibitor

    Phosphodiesterase 9 inhibitors or PDE9 inhibitors are a class of drugs that work by inhibiting the activity of PDE9. The first compound with this effect, BAY 73-6691 , was reported in 2004. [ 1 ] PDE9 inhibitors are under investigation for the treatment of obesity, [ 2 ] hepatic fibrosis , [ 3 ] Alzheimer's disease , schizophrenia , other ...

  9. EC50 - Wikipedia

    en.wikipedia.org/wiki/EC50

    The EC 10 and EC 90 concentrations to induce 10% and 90% maximal responses are defined similarly. There is a wide range of EC 50 values of drugs; they are typically anywhere from nM to mM. Hence, it is often more practical to refer to the logarithmically transformed p EC 50 values instead of EC 50 , where