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The first historical achievement in anesthesia occurred around 4000 BC in ancient Mesopotamia. [5] [10] [33] [34] [35] This was the advent of Ethanol (commonly known as ‘drinking alcohol’), the first general anaesthetic agent.
Since general anesthesia first became widely used in late 1846, assessment of anesthetic depth was a problem. To determine the depth of anesthesia, the anesthetist relies on a series of physical signs of the patient .
One commonly used premedication is clonidine, an alpha-2 adrenergic agonist. [ 23 ] [ 24 ] It reduces postoperative shivering, postoperative nausea and vomiting , and emergence delirium . [ 6 ] However, a randomized controlled trial from 2021 demonstrated that clonidine is less effective at providing anxiolysis and more sedative in children of ...
Additional healthcare professionals involved in anesthesia provision have varying titles and roles depending on the jurisdiction, and include anesthetic nurses, nurse anesthetists, anesthesiologist assistants, anaesthetic technicians, anaesthesia associates, operating department practitioners and anesthesia technologists.
Structures of general anaesthetics widely used in medicine. [1] 1 - ethanol, 2 - chloroform, 3 - diethyl ether, 4 - fluroxene, 5 - halothane, 6 - methoxyflurane, 7 - enflurane, 8 - isoflurane, 9 - desflurane, 10 - sevoflurane. A general anaesthetic (or anesthetic) is a drug that brings about a reversible loss of consciousness. [2]
Healthcare providers can control the rate of anesthesia induction and final tissue concentrations of the anesthetic by varying the partial pressure of the inspired anesthetic. A higher drug partial pressure in the lungs will drive diffusion more rapidly throughout the body and yield a higher maximum tissue concentration.
The first known physician in China to describe the use anesthesia for patients undergoing surgery was the Eastern Han physician Hua Tuo (d. 208 AD), who utilized his knowledge of Chinese herbology based in the Huangdi neijing to create an ointment that healed surgical wounds within a month. [13]
Anesthesiology, anaesthesiology or anaesthesia is the medical specialty concerned with the total perioperative care of patients before, during and after surgery. [1] It encompasses anesthesia, intensive care medicine, critical emergency medicine, and pain medicine. [2]