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  2. Bone morphogenetic protein 2 - Wikipedia

    en.wikipedia.org/wiki/Bone_morphogenetic_protein_2

    Function. BMP-2 like other bone morphogenetic proteins, [6] plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine -cytokine receptor interaction. It is also involved in cardiac cell differentiation and epithelial to mesenchymal transition.

  3. Bone morphogenetic protein - Wikipedia

    en.wikipedia.org/wiki/Bone_morphogenetic_protein

    Bone morphogenetic protein. Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals ...

  4. Bone morphogenetic protein receptor - Wikipedia

    en.wikipedia.org/wiki/Bone_morphogenetic_protein...

    1216. Bone morphogenetic protein receptors are serine-threonine kinase receptors. Transforming growth factor beta family proteins bind to these receptors. [1] There are four bone morphogenetic protein receptors: [2] Bone morphogenetic protein receptor, type 1: ACVR1. BMPR1A.

  5. Bone growth factor - Wikipedia

    en.wikipedia.org/wiki/Bone_growth_factor

    A bone growth factor is a growth factor that stimulates the growth of bone tissue. [1] [2]Known bone growth factors include insulin-like growth factor-1 (IGF-1), insulin-like growth factor-2 (IGF-2), transforming growth factor beta (TGF-β), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), parathyroid hormone-related peptide (PTHrP), bone morphogenetic proteins (BMPs ...

  6. Noggin (protein) - Wikipedia

    en.wikipedia.org/wiki/Noggin_(protein)

    Noggin (protein) Noggin, also known as NOG, is a protein that is involved in the development of many body tissues, including nerve tissue, muscles, and bones. In humans, noggin is encoded by the NOG gene. [5] The amino acid sequence of human noggin is highly homologous to that of rat, mouse, and Xenopus (an aquatic frog genus).

  7. Osteoblast - Wikipedia

    en.wikipedia.org/wiki/Osteoblast

    Key growth factors in endochondral skeletal differentiation include bone morphogenetic proteins (BMPs) that determine to a major extent where chondrocyte differentiation occurs and where spaces are left between bones. The system of cartilage replacement by bone has a complex regulatory system.

  8. Transforming growth factor beta superfamily - Wikipedia

    en.wikipedia.org/wiki/Transforming_growth_factor...

    The transforming growth factor beta (TGF-β) superfamily is a large group of structurally related cell regulatory proteins that was named after its first member, TGF-β1, originally described in 1983. [2] They interact with TGF-beta receptors. Many proteins have since been described as members of the TGF-β superfamily in a variety of species ...

  9. BMP2K - Wikipedia

    en.wikipedia.org/wiki/BMP2K

    This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal.

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