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Marked atypia of type 2 pneumocytes is a characteristic finding in association with treatment with busulfan and other chemotherapeutic agents.. Atypia (from Greek, a + typos, without type; a condition of being irregular or nonstandard) [1] is a histopathologic term for a structural abnormality in a cell, i.e. it is used to describe atypical cells.
A dysplastic nevus or atypical mole is a nevus ... and malignancy potential. When an atypical mole has been identified, ... (negative or free of melanocytic nevus ...
The likelihood of the development to cancer is related to the degree of dysplasia. [11] Dysplasia is the earliest form of precancerous lesion which pathologists can recognize in a pap smear or in a biopsy. Dysplasia can be low grade or high grade. The risk of low-grade dysplasia transforming into high-grade dysplasia, and eventually cancer, is low.
Nuclear atypia refers to abnormal appearance of cell nuclei. It is a term used in cytopathology and histopathology. Atypical nuclei are often pleomorphic. Nuclear atypia can be seen in reactive changes, pre-neoplastic changes and malignancy. Severe nuclear atypia is, in most cases, considered an indicator of malignancy.
The Paris System for reporting urine cytology, version 2.0, ranging from negative to positive for high grade urothelial carcinoma. [1] Urine cytology is a test that looks for abnormal cells in urine under a microscope. The test commonly checks for infection, inflammatory disease of the urinary tract, cancer, or precancerous conditions.
The resection is an attempt to remove a cancer tumor so that no portion of the malignant growth extends past the edges or margin of the removed tumor and surrounding tissue. These are retained after the surgery and examined microscopically by a pathologist to see if the margin is indeed free from tumor cells (called "negative"). If cancerous ...
Therefore, cellular and nuclear pleomorphism is one of the earliest hallmarks of cancer progression and a feature characteristic of malignant neoplasms and dysplasia. [2] [3] Certain benign cell types may also exhibit pleomorphism, e.g. neuroendocrine cells, Arias-Stella reaction.
A neoplasm can be benign, potentially malignant, or malignant . [9] Benign tumors include uterine fibroids, osteophytes, and melanocytic nevi (skin moles). They are circumscribed and localized and do not transform into cancer. [8] Potentially-malignant neoplasms include carcinoma in situ. They are localised, and do not invade and destroy but in ...