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The history of syphilis has been well studied, but the exact origin of the disease was the source of debate until archaeological and genetic evidence showed conclusively it originated in the Americas.
Congenital syphilis is syphilis that occurs when a mother with untreated syphilis passes the infection to her baby during pregnancy or at birth. [4] It may present in the fetus , infant , or later. [ 1 ] [ 5 ] Clinical features vary and differ between early onset, that is presentation before 2-years of age, and late onset, presentation after ...
Treatment at this stage solely limits further progression of the disease and has a limited effect on damage which has already occurred. [3] Serologic cure can be measured when the non-treponemal titers decline by a factor of 4 or more in 6–12 months in early syphilis or 12–24 months in late syphilis. [21]
Arsphenamine, also known as Salvarsan or compound 606, is an antibiotic drug that was introduced at the beginning of the 1910s as the first effective treatment for the deadly infectious diseases syphilis, relapsing fever, and African trypanosomiasis. [2] [3] This organoarsenic compound was the first modern antimicrobial agent. [4]
Cause of death disputed, but symptoms match to mercury poisoning from syphilis treatment. [10] Robert Schumann (1810–1856), German composer Acquired syphilis from a prostitute in the age of 21. [11] Bram Stoker (1847–1912), Irish author Cause of death listed as "Locomotor ataxia 6 months", presumed to be a reference to syphilis. [12] [13]
Hinton developed a flocculation test for syphilis in 1927, and co-developed another syphilis test using spinal fluid with a colleague that would come to be known as the Davies-Hinton test. These tests were considered a boon for medicine, as the treatment for syphilis at the time was long, painful, and hazardous.
Syphilis was the disease most commonly targeted by premarital examination laws. Syphilis was relatively widespread in the first half of the twentieth century, estimated to affect more than 10% of Americans during their lifetime, with many of those afflicted unaware that they were carrying the disease. [ 3 ]
The clinical features of syphilis, yaws, and bejel occur in multiple stages that affect the skin. The skin lesions observed in the early stage last for weeks or months. The skin lesions are highly infectious, and the spirochetes in the lesions are transmitted by direct contact. The lesions regress as the immune response develops against T ...