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Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Vitamin B 12 is a critical micronutrient essential for supporting the increasing metabolic demands of the foetus during pregnancy. [38] B 12 deficiency in pregnant women is increasingly common [39] and has been shown to be associated with major maternal health implications, including increased obesity, [39] higher body mass index (BMI), [40 ...
Many pregnant and nursing mothers don't know that a vitamin B12 deficiency can have serious and lasting effects on your baby. Here's why and what to do about it. B12 Benefits While Pregnant
[41] [39] During pregnancy the placenta concentrates B 12, so that newborn infants have a higher serum concentration than their mothers. [12] As it is recently absorbed vitamin content that more effectively reaches the placenta, the vitamin consumed by the mother-to-be is more important than that contained in her liver tissue. [12] [42]
Low maternal vitamin B 12, defined as serum concentration less than 148 pmol/L, increases the risk of miscarriage, newborn low birth weight and preterm birth. [36] [34] During pregnancy the placenta concentrates B 12, so that newborn infants have a higher serum concentration than their mothers. [33]
Doxylamine is used in the combination drug pyridoxine/doxylamine to treat morning sickness (nausea and vomiting of pregnancy). [ 19 ] [ 20 ] [ 21 ] It is the only medication approved by the United States Food and Drug Administration for the treatment of morning sickness.
Deficiency in pregnant women can lead to birth defects, particularly neural tube defects such as spina bifida and anencephaly. Vitamin B 12: Cobalamins: Vitamin B 12 deficiency results in a macrocytic anemia, elevated methylmalonic acid and homocysteine, peripheral neuropathy, sense loss
[56] [57] Low levels of serum vitamin B 12 may be caused by other factors than B 12 deficiency, such as folate deficiency, pregnancy, oral contraceptive use, haptocorrin deficiency, and myeloma. [57] High serum levels may caused by supplementing with vitamin B 12, present of antibodies to intrinsic factor, or due to underlying condition. [56]
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