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  2. Spindle checkpoint - Wikipedia

    en.wikipedia.org/wiki/Spindle_checkpoint

    The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during metaphase of mitosis or meiosis that prevents the separation of the duplicated chromosomes until each chromosome is properly attached to the ...

  3. Herbert screw - Wikipedia

    en.wikipedia.org/wiki/Herbert_screw

    The Herbert screw (invented by Timothy Herbert) is a variable pitch cannulated screw typically made from titanium for its biocompatible properties as the screw is normally intended to remain in the patient indefinitely. It became generally available in 1978.

  4. Mad2 - Wikipedia

    en.wikipedia.org/wiki/MAD2

    The spindle checkpoint system is a regulatory system that restrains progression through the metaphase-to-anaphase transition. The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons. [ 1 ]

  5. Meiotic recombination checkpoint - Wikipedia

    en.wikipedia.org/wiki/Meiotic_recombination...

    Meiotic recombination may begin with a double-strand break, either induced by Spo11 [2] or by other endogenous or exogenous causes of DNA damage. These DNA breaks must be repaired before metaphase I. and these DSBs must be repaired before metaphase I. The cell monitor these DSBs via ATM pathway, in which Cdc25 is suppressed when DSB lesion is ...

  6. Metaphase - Wikipedia

    en.wikipedia.org/wiki/Metaphase

    Metaphase (from Ancient Greek μετα- beyond, above, transcending and from Ancient Greek φάσις (phásis) 'appearance') is a stage of mitosis in the eukaryotic cell cycle in which chromosomes are at their second-most condensed and coiled stage (they are at their most condensed in anaphase). [1]

  7. Spindle apparatus - Wikipedia

    en.wikipedia.org/wiki/Spindle_apparatus

    It is referred to as the mitotic spindle during mitosis, a process that produces genetically identical daughter cells, or the meiotic spindle during meiosis, a process that produces gametes with half the number of chromosomes of the parent cell. Besides chromosomes, the spindle apparatus is composed of hundreds of proteins.

  8. Biorientation - Wikipedia

    en.wikipedia.org/wiki/Biorientation

    Biorientation is the phenomenon whereby microtubules emanating from different microtubule organizing centres (MTOCs) attach to kinetochores of sister chromatids.This results in the sister chromatids moving to opposite poles of the cell during cell division, and thus results in both daughter cells having the same genetic information.

  9. Cell cycle checkpoint - Wikipedia

    en.wikipedia.org/wiki/Cell_cycle_checkpoint

    The G 2-M checkpoint occurs between the G 2 and M phases. The spindle checkpoint occurs during the M phase. Key cyclins associated with each phase are shown. Cell cycle checkpoints are control mechanisms in the eukaryotic cell cycle which ensure its proper progression.

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