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The first pharmacokinetic model described in the scientific literature [2] was in fact a PBPK model. It led, however, to computations intractable at that time. The focus shifted then to simpler models, [3] for which analytical solutions could be obtained (such solutions were sums of exponential terms, which led to further simplifications.)
In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation. [1]By definition, when a medication is administered intravenously, its bioavailability is 100%.
Bootstrapping populations in statistics and mathematics starts with a sample {, …,} observed from a random variable.. When X has a given distribution law with a set of non fixed parameters, we denote with a vector , a parametric inference problem consists of computing suitable values – call them estimates – of these parameters precisely on the basis of the sample.
On the morning of May 26, 2012, 31-year-old Rudy Eugene drove to Miami Beach, Florida, to Urban Beach Week. [5] After spending 30–40 minutes at the site, as filmed on security video in and around the car, [5] he abandoned it around noon and began to cross the 3-mile-long (4.8 km) span of the MacArthur Causeway, stripping himself of his clothing and disposing of his driver's license as he ...
the altar used for Mass by Pope John Paul II while visiting Clonmacnoise. Pope John Paul began the second day of his tour with a short visit to the ancient monastery at Clonmacnoise in County Offaly. [5]