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Merkel nerve endings (also Merkel's disks, [1] or Merkel tactile endings [2]) are mechanoreceptors situated in the basal epidermis as well as around the apical ends or some hair follicles. [2] They are slowly adapting. They have small receptive fields measuring some milimeters in diameter. Most are associated with fast-conducting large ...
Merkel cells, also known as Merkel–Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for light touch sensation and found in the skin of vertebrates. They are abundant in highly sensitive skin like that of the fingertips in humans , and make synaptic contacts with somatosensory afferent nerve fibers .
The Slowly Adapting type 1 (SA1) mechanoreceptor, with the Merkel corpuscle end-organ (also known as Merkel discs) detect sustained pressure and underlies the perception of form and roughness on the skin. [1] They have small receptive fields and produce sustained responses to static stimulation. [citation needed]
Merkel's Disks - Located on the upper part of the dermis. Slow adapting receptors. Found on the fingertips as well as the eyelids. Meissner's Corpuscles - Located also on the upper part of the dermis. Found on the hairless skin including the lips as well as the eyelids. These are rapid adapting receptors.
As with all skin cancers, sun exposure is a risk factor, as is a compromised immune system and previous history of skin cancer.
The Pacinian corpuscles are located within the deeper layer of the skin, under the skin in the subcutaneous tissues, within muscles, in the periosteum, and other deeper layers of the body. The Merkel disk receptors are located in the superficial epidermis and in hair follicles, while tactile corpuscles are concentrated heavily in the fingertips ...
Merkel cell carcinoma (also known as Merkel cell skin cancer) is a rare type of cancer where malignant cells form in the skin, according to the National Cancer Institute (NCI).
It is located in the cytoplasm and forms a α-hydrophobic helix called S1; the region between the transmembrane domains form a loop that is divided into two regions: S2 a glycine-proline rich region and S3 a short helical section. [81] The secondary structure of the protein is resistant to thermal denaturation still in the presence of SDS. [82]