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Bismuth salts were in use in Europe by the late 1700s. The combination of bismuth subsalicylate and zinc salts for astringency with salol (phenyl salicylate) appears to have begun in the US in the early 20th century as a remedy for life-threatening diarrhea in infants with cholera.
As a consequence, since 2004, bismuth subsalicylate has been used as the active ingredient in U.S. marketed products. [2] In Canada, McNeil Consumer Healthcare continues to market Kaopectate using attapulgite as the active ingredient. However, Kaopectate was recalled in July 2021 in Canada because it may contain arsenic and lead beyond ...
Bismuth subsalicylate (BSS) has both antibacterial and anti-secretory actions that help with diarrhea. [1] Once in the gut, BSS gets broken down into bismuth and salicylic acid. [ 1 ] Bismuth produces other bismuth salts, which blocks the binding and proliferation of bacteria in stomach mucosal cells, leading to a decrease in inflammation in ...
Eluxadoline, sold under the brand names Viberzi and Truberzi, [3] is a medication taken by mouth for the treatment of diarrhea and abdominal pain in individuals with diarrhea-predominant irritable bowel syndrome (IBS-D). [4]
Anti-inflammatory compounds such as bismuth subsalicylate. Anticholinergics reduce intestinal movement and are effective against both diarrhoea and accompanying cramping. Opioids' classical use besides pain relief is as an anti-diarrhoeal drug. Opioids have agonist actions on the intestinal opioid receptors, which when activated cause constipation.
Early on, these may be subtle, while larger doses may result in fever. [1] [4] Complications can include swelling of the brain or lungs, seizures, low blood sugar, or cardiac arrest. [1] While usually due to aspirin, other possible causes include oil of wintergreen and bismuth subsalicylate. [2] Excess doses can be either on purpose or ...
An experimental nasal spray has helped clear toxic protein buildups in the brains of mouse models of Alzheimer's. Its developers believe the spray may help delay Alzheimer's by at least a decade.
Kussmaul suggests using bismuth compounds, an antibacterial agent, to treat peptic ulcers (bismuth subsalicylate has since been used in many commercial drugs, including Pepto Bismol as part of antibacterial H. pylori treatment). The antibacterial properties of bismuth were not known until much later. [1] 1875