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Metastasis is the most common cause of brain cancer, as primary tumors that originate in the brain are less common. [4] The most common sites of primary cancer which metastasize to the brain are lung, breast, colon, kidney, and skin cancer. Brain metastases can occur months or even years after the original or primary cancer is treated.
About one in three people diagnosed with lung cancer have symptoms caused by metastases in sites other than the lungs. [7] Lung cancer can metastasize anywhere in the body, with different symptoms depending on the location. Brain metastases can cause headache, nausea, vomiting, seizures, and neurological deficits.
Secondary, or metastatic, brain tumors are about four times as common as primary brain tumors, [2] [10] with about half of metastases coming from lung cancer. [2] Primary brain tumors occur in around 250,000 people a year globally, and make up less than 2% of cancers. [3]
Metastasis occurrence indicates stage 4 cancer progression and carries a poor prognosis. [7] Cancer usually causes numerous and varying symptoms at this stage depending on the underlying cancer and metastasis location. [7] Importantly for diagnosis, a symptomatic primary lesion is localised through either surgery or radiation. [7]
The base of the skull may be affected by metastases from cancer of the bronchus, breast or prostate, or cancer may spread directly to this area from the nasopharynx , and this may cause headache, facial paresthesia, dysesthesia or pain, or cranial nerve dysfunction – the exact symptoms depend on the cranial nerves impacted. [4]
Neuroendocrine tumors of the lung [7] Lymphomas of the lung. [8] Sarcomas of the lung. [9] Some rare vascular tumors of the lung [8] Non-lung tumors which may grow into the lungs: Mediastinal tumors; Pleural tumors; Metastasis or secondary tumors/neoplasms with other origin: Metastasis to the lung
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Signs and symptoms are not mutually exclusive, for example a subjective feeling of fever can be noted as sign by using a thermometer that registers a high reading. [7] Because many symptoms of cancer are gradual in onset and general in nature, cancer screening (also called cancer surveillance) is a key public health priority. This may include ...
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