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Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]
[15] [30] In March 2014, it was approved for the additional indication of preventing deep vein thrombosis and pulmonary embolism in people who have recently undergone knee or hip replacement. [ 31 ] [ 32 ] In August 2014, the FDA approved apixaban for the additional indication of the treatment of recurring deep vein thrombosis and pulmonary ...
Equianalgesic charts are also used when calculating an equivalent dosage of the same ... 2 ⁄ 5: 25 mg ... ; 2–5 min 3–4 hours N-Phenethylnormorphine: 8–14 ...
The LD 50 for warfarin is 50–100 mg/kg for a single dose, after 5–7 days. [109] LD 50 1 mg/kg for repeated daily doses for 5 days, after 5–8 days. [109] The IDLH value is 100 mg/m 3 (warfarin; various species). [111] Resistance to warfarin as a poison has developed in many rat populations due to an autosomal dominant on chromosome 1 in ...
Low-molecular-weight heparin (LMWH) is a class of anticoagulant medications. [1] They are used in the prevention of blood clots and, in the treatment of venous thromboembolism (deep vein thrombosis and pulmonary embolism), and the treatment of myocardial infarction.
Primary Indication Company 2015 2014 2013 2012 2011 2010 2009 ... rivaroxaban: Xarelto Deep vein thrombosis Johnson & Johnson [39] $1,868 $1,522 $864 $239 $25
The drug is highly cardioselective at 5 mg. [19] In addition, at doses above 10 mg, nebivolol loses its cardioselectivity and blocks both β1 and β2 receptors, [18] while the recommended starting dose of nebivolol is 5 mg, sufficient control of blood pressure may require doses up to 40 mg. [18] Furthermore, nebivolol is also not ...
Following an IV bolus of bivalirudin of 1 mg/kg and a 4-hour 2.5 mg/kg/h IV infusion a mean steady state concentration of 12.3 ± 1.7 μg/mL is achieved [2] Bivalirudin is cleared from plasma by a combination of renal mechanisms and proteolytic cleavage; Half-life:-Normal renal function (≥ 90 mL/min) = 25 minutes
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