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  2. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Rivaroxaban inhibits both free and bound Factor Xa in the prothrombinase complex. [33] It is a selective direct factor Xa inhibitor with an onset of action of 2.5 to 4 hours. [34] Inhibition of Factor Xa interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade, inhibiting both thrombin formation and development of thrombi.

  3. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    Apixaban is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes, or symptomatic heart failure.

  4. Rheumatoid arthritis - Wikipedia

    en.wikipedia.org/wiki/Rheumatoid_arthritis

    This is 0.5–1% of adults in the developed world with between 5 and 50 per 100,000 people newly developing the condition each year. [3] Onset is most frequent during middle age and women are affected 2.5 times as frequently as men. [1] It resulted in 38,000 deaths in 2013, up from 28,000 deaths in 1990. [11]

  5. Best arthritis pain relief cream of 2024, according to experts

    www.aol.com/lifestyle/arthritis-pain-relief...

    Cost: $19.22 for 5.3 oz tube | Key Ingredients: Diclofenac sodium (NSAID) 1% (equivalent to 0.93% diclofenac) | Cooling, ... To determine the best arthritis pain relief creams, we consulted with ...

  6. Riociguat - Wikipedia

    en.wikipedia.org/wiki/Riociguat

    One of the first studies was designed to test the safety profile, pharmacokinetics and pharmacodynamics of single oral doses of riociguat (0.25–5 mg). 58 healthy male subjects were given riociguat orally (oral solution or immediate-release tablet) in a randomised, placebo-controlled trial.

  7. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.

  8. Analgesic - Wikipedia

    en.wikipedia.org/wiki/Analgesic

    An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management.Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and ...

  9. Arachidonate 5-lipoxygenase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Arachidonate_5-lipoxygen...

    Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes. The overproduction of leukotrienes is a major cause of inflammation in asthma, allergic rhinitis, and osteoarthritis. [1] [2]

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