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Animal studies showed that these compounds lowered blood glucose levels. Some less toxic derivatives, synthalin A and synthalin B, were used for diabetes treatment, but after the discovery of insulin, their use declined. Biguanides were reintroduced into Type 2 diabetes treatment in the late 1950s.
The Common Terminology Criteria for Adverse Events (CTCAE), [1] formerly called the Common Toxicity Criteria (CTC or NCI-CTC), are a set of criteria for the standardized classification of adverse events of drugs and treatment used in cancer therapy. The CTCAE system is a product of the US National Cancer Institute (NCI).
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, [ 4 ] it is spelled polihexanide ( INN ) and sold under various brand names. [ 5 ]
Exposure to lower levels of cyanide over a long period (e.g., after use of improperly processed cassava roots; cassava is a staple food in various parts of West Africa) results in increased blood cyanide levels, which can result in weakness and a variety of symptoms, including permanent paralysis, nervous lesions, [14] [15] [16] hypothyroidism ...
Acute toxicity describes the adverse effects of a substance that result either from a single exposure [1] or from multiple exposures in a short period of time (usually less than 24 hours). [ 2 ] To be described as acute toxicity, the adverse effects should occur within 14 days of the administration of the substance.
Causes: Chronic vitamin B 6 supplementation, or acute parenteral or oral over‐dosages of vitamin B 6. [5] [4] [6] [7] [8] Risk factors: Impaired kidney function, parenteral nutrition [9] Diagnostic method: Serum testing for elevated levels of vitamin B 6, testing of tendon reflexes, nerve conduction studies and electrodiagnostic testing. [10 ...
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The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech. Severe symptoms include coma and respiratory depression. Supportive care is the mainstay of treatment of benzodiazepine overdose. There is an antidote, flumazenil, but its use is controversial. [2]