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  2. Median lethal dose - Wikipedia

    en.wikipedia.org/wiki/Median_lethal_dose

    In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.

  3. Toxicity class - Wikipedia

    en.wikipedia.org/wiki/Toxicity_class

    The system is based on LD50 determination in rats, thus an oral solid agent with an LD50 at 5 mg or less/kg bodyweight is Class Ia, at 5–50 mg/kg is Class Ib, LD50 at 50–2000 mg/kg is Class II, and at LD50 at the concentration more than 2000 mg/kg is classified as Class III. Values may differ for liquid oral agents and dermal agents. [1]

  4. Lethal dose - Wikipedia

    en.wikipedia.org/wiki/Lethal_dose

    In toxicology, the lethal dose (LD) is an indication of the lethal toxicity of a given substance or type of radiation.Because resistance varies from one individual to another, the "lethal dose" represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given percentage of subjects will die.

  5. HAZMAT Class 6 Toxic and infectious substances - Wikipedia

    en.wikipedia.org/wiki/HAZMAT_Class_6_Toxic_and...

    Dermal Toxicity: LD 50 for acute dermal toxicity means that dose of the material which, administered by continuous contact for 24 hours with the shaved intact skin (avoiding abrading) of an albino rabbit, causes death within 14 days in half of the animals tested. The number of animals tested must be sufficient to give statistically valid ...

  6. List of dangerous snakes - Wikipedia

    en.wikipedia.org/wiki/List_of_dangerous_snakes

    The median lethal dose (LD 50) of a venom is the dose required to kill half the members of a tested population after a specified test duration. A lower LD 50 number indicates increased toxicity. There are four methods in which the LD 50 test is measured: Subcutaneous: Venom is injected into the fatty layer beneath the skin.

  7. Nicotine poisoning - Wikipedia

    en.wikipedia.org/wiki/Nicotine_poisoning

    The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...

  8. List of highly toxic gases - Wikipedia

    en.wikipedia.org/wiki/List_of_highly_toxic_gases

    Many gases have toxic properties, which are often assessed using the LC 50 (median lethal concentration) measure. In the United States, many of these gases have been assigned an NFPA 704 health rating of 4 (may be fatal) or 3 (may cause serious or permanent injury), and/or exposure limits (TLV, TWA/PEL, STEL, or REL) determined by the ACGIH professional association.

  9. Theobromine poisoning - Wikipedia

    en.wikipedia.org/wiki/Theobromine_poisoning

    Theobromine is less toxic to rats and mice, who all have an LD 50 of about 1,000 mg/kg (0.016 oz/lb). In dogs, the biological half-life of theobromine is 17.5 hours; in severe cases, clinical symptoms of theobromine poisoning can persist for 72 hours. [ 12 ]