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Blackish discoloration with vesicle formation on the thigh in a case of necrotizing fasciitis. Necrotizing fasciitis (NF), also known as flesh-eating disease, is a bacterial infection that results in the death of parts of the body's soft tissue. [3] It is a severe disease of sudden onset that spreads rapidly. [3]
Gas gangrene (also known as clostridial myonecrosis [1]) is a bacterial infection that produces tissue gas in gangrene. This deadly form of gangrene usually is caused by Clostridium perfringens bacteria. About 1,000 cases of gas gangrene are reported yearly in the United States. [2] Myonecrosis is a condition of necrotic damage, specific to ...
Gas gangrene is a bacterial infection that produces gas within tissues. It can be caused by Clostridium , most commonly alpha toxin -producing C. perfringens , or various nonclostridial species. [ 9 ] [ 19 ] Infection spreads rapidly as the gases produced by the bacteria expand and infiltrate healthy tissue in the vicinity.
Deeper anaerobic soft-tissue infections are necrotizing fasciitis, necrotizing synergistic cellulitis, gas gangrene and crepitus cellulitis. These can involve the fascia as well as the muscle surrounded by the fascia, and may also induce myositis and myonecrosis. [citation needed]
Infection of GAS may spread through direct contact with mucus or sores on the skin. [2] GAS infections can cause over 500,000 deaths per year. [4] Despite the emergence of antibiotics as a treatment for group A streptococcus, cases of iGAS are an increasing problem, particularly on the continent of Africa. [5]
S. pyogenes invasion and multiplication in the fascia beneath the skin can lead to necrotizing fasciitis, a life-threatening surgical emergency. [35] [36] The bacterium is also an important cause of infection in newborns, who are susceptible to some forms of the infection that are rarely seen in adults, including meningitis. [37] [38]
Ecthyma gangrenosum is a type of skin lesion characterized by vesicles or blisters which rapidly evolve into pustules and necrotic ulcers with undermined tender erythematous border.
[1] [3] Before making a diagnosis, more serious infections such as an underlying bone infection or necrotizing fasciitis should be ruled out. [4] Treatment is typically with antibiotics taken by mouth, such as cephalexin, amoxicillin or cloxacillin. [1] [6] Those who are allergic to penicillin may be prescribed erythromycin or clindamycin ...