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Gas gangrene (also known as clostridial myonecrosis [1]) is a bacterial infection that produces tissue gas in gangrene. This deadly form of gangrene usually is caused by Clostridium perfringens bacteria. About 1,000 cases of gas gangrene are reported yearly in the United States. [2] Myonecrosis is a condition of necrotic damage, specific to ...
Clostridium perfringens is the most common bacterial agent for gas gangrene. [47] Gas gangrene is induced by α-toxin that embeds itself into the plasma membrane of cells and disrupts normal cellular function by altering membrane structure. [43] Some symptoms include blisters, tachycardia, swelling, and jaundice. [47]
It is thought that the infection is established by hematogenous spread from the gastrointestinal tract. Gas gangrene caused by Clostridium septicum is associated with colorectal cancer and other defects of the bowel. [2] Clostridium septicum causes myonecrosis through the release of exotoxins such as the alpha toxin, lethal toxin, and hemolytic ...
Gas gangrene is a bacterial infection that produces gas within tissues. It can be caused by Clostridium , most commonly alpha toxin -producing C. perfringens , or various nonclostridial species. [ 9 ] [ 19 ] Infection spreads rapidly as the gases produced by the bacteria expand and infiltrate healthy tissue in the vicinity.
This toxin has been shown to be the key virulence factor in infection with C. perfringens; the bacterium is unable to cause disease without this toxin. [1] Further, vaccination against the alpha toxin toxoid protects mice against C. perfringens gas gangrene. [2]
Air can be trapped under the skin in necrotizing infections such as gangrene, occurring as a late sign in gas gangrene, [2] of which it is the hallmark sign. Subcutaneous emphysema is also considered a hallmark of Fournier gangrene. [26] Symptoms of subcutaneous emphysema can result when infectious organisms produce gas by fermentation. When ...
Group A streptococcal infections are a number of infections with Streptococcus pyogenes, a group A streptococcus (GAS). [1] S. pyogenes is a species of beta-hemolytic Gram-positive bacteria that is responsible for a wide range of infections that are mostly common and fairly mild.
Skin involvement in subcutaneous tissue infections includes: cutaneous and subcutaneous abscesses, [37] breast abscess, decubitus ulcers, infected pilonidal cyst or sinus, Meleney's ulcer infected diabetic (vascular or trophic) ulcers, bite wound, [38] anaerobic cellulitis and gas gangrene, bacterial synergistic gangrene, and burn wound ...