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Trazodone has a minor active metabolite known as meta-chlorophenylpiperazine (mCPP), and this metabolite may contribute to some degree to the pharmacological properties of trazodone. [ 11 ] [ 110 ] In contrast to trazodone, mCPP is an agonist of various serotonin receptors. [ 111 ]
mCPP is a metabolite of a variety of other piperazine drugs including trazodone, nefazodone, etoperidone, enpiprazole, mepiprazole, cloperidone, peraclopone, and BRL-15,572. [52] [additional citation(s) needed] It is formed by dealkylation via CYP3A4. [52]
This is a list of adverse effects of the antidepressant trazodone, sorted by frequency of occurrence. [1] [2] [3] Very common.
Chemical structure of the serotonin antagonist and reuptake inhibitor trazodone. Serotonin antagonist and reuptake inhibitors ( SARIs ) are a class of drugs used mainly as antidepressants , but also as anxiolytics and hypnotics .
It is both a precursor in the synthesis of aripiprazole and one of its metabolites. [ 1 ] [ 2 ] It is unclear whether 2,3-DCPP is pharmacologically active as a serotonin receptor agonist similar to its close analogue 3-chlorophenylpiperazine ( m CPP), though it has been shown to act as a partial agonist of the dopamine D 2 and D 3 receptors.
PNU-181731 is a drug which acts as an agonist at serotonin 5-HT 2 receptors, [1] [2] with strongest binding affinity for the 5-HT 2C subtype at 4.8nM, and weaker 5-HT 2A affinity of 18nM.
An atypical antidepressant is any antidepressant medication that acts in a manner that is different from that of most other antidepressants. Atypical antidepressants include agomelatine, bupropion, iprindole, mianserin, mirtazapine, nefazodone, opipramol, tianeptine, and trazodone.
Loxapine (Adasuve, Loxitane) – a typical antipsychotic that produces amoxapine as a major metabolite and is said to have antidepressant effects, but it is not usually regarded as a TeCA; Drugs that contain four rings not all fused together but could still be classified as tetracyclic include: