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While knowledge was being accumulated regarding the biology of phages and how to use phage cocktails correctly, early uses of phage therapy were often unreliable. [29] Since the early 20th century, research into the development of viable therapeutic antibiotics had also been underway, and by 1942, the antibiotic penicillin G had been ...
George Eliava pioneered the use of phages in treating bacterial infections. Phages were discovered to be antibacterial agents and were used in the former Soviet Republic of Georgia (pioneered there by Giorgi Eliava with help from the co-discoverer of bacteriophages, Félix d'Hérelle) during the 1920s and 1930s for treating bacterial infections.
Production problems were most likely due to the attempt to mass-produce phages when they were barely understood. The phages may have been damaged and/or too low in concentration. Another possibility is that incorrect diagnoses led to the use of the irrelevant types of phages that were not adapted to the host bacteria of interest. Many studies ...
Many of the leaders of the emerging field of molecular biology were alumni of the phage course, which continued to be taught through the 1950s and 1960s. [ 24 ] [ 25 ] In 1995, Millard Susman published a retrospective article on the phage course as it was given over the years (1945 – 1970) both at Cold Spring Harbor (New York) and at the ...
The Mongol Empire established commercial and political connections between the Eastern and Western areas of the world, through the most mobile army ever seen. The armies, composed of the most rapidly moving travelers who had ever moved between the steppes of East Asia (where bubonic plague was and remains endemic among small rodents), managed to keep the chain of infection without a break ...
Characteristics given are cluster assignment, number of subclusters (Sub.), number of phages in the cluster, host species from which the phages were isolated, the average genome size, average percent GC content, average number of ORFS, and the morphotype. Species abbreviations are Bacillus anthracis (A), Bacillus cereus (C), Bacillus sp.
Despite the World War I-era interest in ricin, as World War II erupted, the United States Army still maintained the position that biological weapons were, for the most part, impractical. [2] Other nations, notably France, Japan and the United Kingdom, thought otherwise and had begun their own biological weapons programs. [2]
The first phages that were studied in detail included seven that commonly infect E. coli. They were named Type 1 (T1), Type 2 (T2), etc., for easy reference; however, due to structural similarities between the T2, T4, and T6 bacteriophages, these are now commonly referred to as T-Even phages .