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Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells , but also acts on haemopoietic progenitor cells and T cells .
Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene. [5] [6] [7]The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing.
Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. [7] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. [1] Usually it is a secreted protein or a steroid hormone .
The regulatory mechanisms prepare hepatocytes to enter the cell cycle. The proliferation phase involves activation of various growth factors, including two factors that play a major role in liver regeneration, EGFR (epidermal growth factor receptor) and c-Met. During this phase, hepatocytes undergo a series of cell division cycles and expansion ...
The transforming growth factor receptor 3 (TGFβR3) is the most abundant of the TGF-β receptors yet, [14] it has no known signaling domain. [15] It however may serve to enhance the binding of TGFβ ligands to TGFβ type II receptors by binding TGFβ and presenting it to TGFβR2.
9146 15239 Ensembl ENSG00000185359 ENSMUSG00000025793 UniProt O14964 Q99LI8 RefSeq (mRNA) NM_004712 NM_001159328 NM_008244 RefSeq (protein) NP_004703 NP_001152800 NP_032270 Location (UCSC) Chr 17: 81.68 – 81.7 Mb Chr 11: 120.36 – 120.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is ...
Branching morphogenesis over two days by Madin-Darby canine kidney cells in response to hepatocyte growth factor (HGF). Images were acquired by fluorescence confocal microscopy, showing the structural protein actin, which highlights cell borders. Left: multicellular hollow spheres of cells, termed acini, were grown in 3D culture.
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