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  2. Hereditary haemochromatosis - Wikipedia

    en.wikipedia.org/wiki/Hereditary_haemochromatosis

    However, HFE is only part of the story, since many patients with mutated HFE do not manifest clinical iron overload, and some patients with iron overload have a normal HFE genotype. A possible explanation is the fact that HFE normally plays a role in the production of hepcidin in the liver, a function that is impaired in HFE mutations. [49]

  3. HFE H63D gene mutation - Wikipedia

    en.wikipedia.org/wiki/HFE_H63D_gene_mutation

    [20] [21] The homozygous H63D variant is an indicator of the iron metabolism disorder hemochromatosis, which may increase the risk of developing a fatty liver. [22] In patients with a cirrhotic liver, the mutation can increase the rate of liver cancer. [6] [23] [24]

  4. HFE (gene) - Wikipedia

    en.wikipedia.org/wiki/HFE_(gene)

    At least 42 mutations involving HFE introns and exons have been discovered, most of them in persons with hemochromatosis or their family members. [25] Most of these mutations are rare. Many of the mutations cause or probably cause hemochromatosis phenotypes, often in compound heterozygosity with HFE C282Y.

  5. Haemochromatosis type 3 - Wikipedia

    en.wikipedia.org/wiki/Haemochromatosis_type_3

    Majority of the cases of hemochromatosis are caused by mutations in the HFE (Homeostatic Iron Regulator) gene. [17] Type 3 HH is characterized by compound heterozygote mutations in both transferrin receptor 2 (TFR2) and HFE, i.e. a single mutation in each gene. HFE is located on chromosome 6 and TFR2 is located on chromosome 7.

  6. Iron overload - Wikipedia

    en.wikipedia.org/wiki/Iron_overload

    Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.

  7. Fatty Liver Disease: What Men Need to Know - AOL

    www.aol.com/fatty-liver-disease-men-know...

    Liver cancer. High blood pressure. Type 2 diabetes. Cardiovascular disease. Metabolic syndrome. Dyslipidemia (abnormal levels of lipids, or fats, in your blood) Prostock-Studio / iStock.

  8. Hemojuvelin - Wikipedia

    en.wikipedia.org/wiki/Hemojuvelin

    Mutations in HJV are responsible for the vast majority of juvenile hemochromatosis patients. A small number of patients have mutations in the hepcidin gene. The gene was positionally cloned. [6] Hemojuvelin is highly expressed in skeletal muscle and heart, and to a lesser extent in the liver.

  9. HIV isn't the death sentence it once was: How related deaths ...

    www.aol.com/hiv-isnt-death-sentence-once...

    It was first identified as a "gay cancer" as it mainly affected gay men and was associated with Kaposi's sarcoma, a rare form of cancer linked to weakened immunity. It further spread among other ...