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CD68 immunostaining demonstrating macrophages and giant cells in a case of xanthogranulomatous pyelonephritis CD68 ( C luster of D ifferentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes , osteoclasts ), by circulating macrophages , and by tissue macrophages (e.g., Kupffer cells , microglia ).
[12] [13] While multinucleate cells are negative for other monocyte/macrophage lineage markers, they are significantly positive for vimentin. [11] [13] CD68 expression can be either positive [11] or negative. [13] [12] In interstitial and perivascular spindle cells, as well as rarely in multinucleate cells, estrogen receptor α has significant ...
The mononuclear phagocytic system is part of the organism's immune system. The histiocyte is a tissue macrophage [1] or a dendritic cell [2] (histio, diminutive of histo, meaning tissue, and cyte, meaning cell). Part of their job is to clear out neutrophils once they've reached the end of their lifespan.
Angiology (from Greek ἀγγεῖον, angeīon, "vessel"; and -λογία, -logia) is the medical specialty dedicated to studying the circulatory system and of the lymphatic system, i.e., arteries, veins and lymphatic vessels. [1] In the UK, this field is more often termed angiology, and in the United States the term vascular medicine is
Anatomical terms of microanatomy [ edit on Wikidata ] A megakaryocyte (from mega- 'large' karyo- ' cell nucleus ' and -cyte ' cell ') is a large bone marrow cell with a lobated nucleus that produces blood platelets (thrombocytes), which are necessary for normal clotting .
The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early haematopoietic and vascular-associated progenitor cells. [13] However, little is known about its exact function. [14] CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes.
Vasculogenesis occurs during embryonic development of the circulatory system. Specifically, around blood islands, which first arise in the mesoderm of the yolk sac at 3 weeks of development. [5] Vasculogenesis can also arise in the adult organism from circulating endothelial progenitor cells (derivatives of stem cells). These cells are able to ...
The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Paris in 1982. [4] [5] This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells).