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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Symptoms of iron overload include fatigue, skin discoloration, and joint and abdominal pain. Can iron pills cause weight gain? There is no direct evidence that iron pills cause weight gain ...
FYI: Signs of iron overload include fatigue, an irregular heartbeat, joint pain, stomach pain and more. Signs of an iron deficiency can be similar—like fatigue—and also include pale or yellow ...
The symptoms of type 4B hemochromatosis tend to be more severe. They resemble the symptoms of hemochromatosis types 1, 2, and 3. Plasma iron concentration is elevated, and symptoms include joint pain, diabetes, and arrhythmia. Liver iron deposition tends to be greater in type 4B than in type 4A. [5]
Individuals with the relevant genetic variants may never develop iron overload. Phenotypic expression is present in 70% of C282Y homozygotes with less than 10% going on to experience severe iron overload and organ damage. [40] The H63D variant is just a gene polymorphism, and if there are no other changes, it may not have clinical significance.
“Do not take iron just because you are experiencing these symptoms, or you risk iron overload, which can bring different problems to the surface,” says Indhira Ghyssaert, M.D., a family ...
“Those who are iron deficient likely feel weakness, headaches, fatigue, pale, and/or have joint pain,” says Eric Ascher, DO, a family medicine physician at Lenox Hill Hospital.
Manifestation of iron poisoning may vary depending on the amount of iron ingested by the individual and is further classified by five stages based on timing of signs and symptoms. In mild to moderate cases, individuals may be asymptomatic or only experience mild gastrointestinal symptoms that resolve within six hours. [ 5 ]