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This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs. [2] Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and implanting them when the body cannot heal itself.
In the mammalian kidney, the regeneration of the tubular component following an acute injury is well known. Recently regeneration of the glomerulus has also been documented. Following an acute injury, the proximal tubule is damaged more, and the injured epithelial cells slough off the basement membrane of the nephron.
The existing epithelial cells can replicate, and, using the basement membrane as a guide, eventually bring the kidney back to normal. After regeneration is complete, the damage is undetectable, even microscopically. [citation needed] Healing must happen by repair in the case of injury to cells that are unable to regenerate (e.g. neurons).
The most common causes of CKD are high blood pressure and diabetes, "which damage the small blood vessels and filtering units in the kidneys over time," says Nagata. Other potential causes he ...
Kidney dysfunction typically develops 1–2 days after the initial muscle damage. [4] If supportive treatment is inadequate to manage this, renal replacement therapy (RRT) may be required. [ 13 ] RRT removes excess potassium, acid and phosphate that accumulate when the kidneys are unable to function normally and is required until kidney ...
When the kidneys are damaged, potassium levels can become elevated. Elevated potassium levels can cause the heart to beat irregularly or even stop. Phosphorus: The kidneys also help to regulate phosphorus levels in the body. When the kidneys are damaged, they aren't able to remove excessive phosphorus, causing it to build up in blood.
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