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Salbutamol, also known as albuterol and sold under the brand name Ventolin among others, [1] is a medication that opens up the medium and large airways in the lungs. [8] It is a short-acting β 2 adrenergic receptor agonist that causes relaxation of airway smooth muscle . [ 8 ]
The UK Department of Health (now the DHSC) agreed to fund the BNFC, as it does the BNF, to ensure that NHS clinicians can have up-to-date information in their pockets. The first edition was published in 2005, with George Rylance [ 7 ] chairing the Paediatric Formulary Committee and Dinesh Mehta as the first executive editor.
The English Prescribing Dataset (EPD) from the NHS Business Services Authority (NHSBSA) provides prescription data in the United Kingdom. [2] The dataset was created in 2014. EPD is a combination of the Detailed Prescribing Information (DPI) and the Practice Level Prescribing in England (PLP).
MDI canister and actuator components from H&T Presspart. A metered-dose inhaler consists of three major components: the canister, which is produced in aluminum or stainless steel by means of deep drawing, where the formulation resides; the metering valve, which allows a metered quantity of the formulation to be dispensed with each actuation; and an actuator (or mouthpiece) which enables the ...
For milder cases, simple reassurance and topical treatment with a calcium channel blocker such as diltiazem, or nifedipine ointment, salbutamol inhalation and topical nitroglycerine. For persistent cases, local anesthetic blocks, clonidine or botulinum toxin injections can be considered.
Ipratropium bromide/salbutamol, sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD). [ 1 ] [ 4 ] [ 5 ] It contains ipratropium (an anticholinergic ) and salbutamol (albuterol, a β 2 -adrenergic agonist ).
Evidence is inconclusive regarding the efficacy of levosalbutamol versus salbutamol or salbutamol-levosalbutamol combinations, though levosalbutamol is believed to have a better safety profile due to its more selective binding to β 2 receptors (primarily in the lungs) versus β 1 (primarily in heart muscle). [2] [3]
Salmeterol lasts approximately 12 hours in comparison with salbutamol, which lasts about 4–6 hours. [ 2 ] [ 9 ] When used regularly every day as prescribed, inhaled salmeterol decreases the number and severity of asthma attacks.