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For most people, recommendations are to reduce blood pressure to less than or equal to somewhere between 140/90 mmHg and 160/100 mmHg. [2] In general, for people with elevated blood pressure, attempting to achieve lower levels of blood pressure than the recommended 140/90 mmHg will create more harm than benefits, [3] in particular for older people. [4]
Goal blood pressure (mmHg) Initial treatment options ESC 2024 [2] General 120–129/70–79 BP >140/90: Two from different classes: preferably RAS-inhibitor (ACEI or ARB) with either thiazide diuretic/thiazide-like diuretic or dihydropyridine CCB. ESH 2023 [3] General age <65 General age 65–79 General age ≥80 <130/80 <140 SBP <150 SBP
The manifestations of histamine intolerance are usually systemic, affecting the entire body; still, these symptoms are often sporadic and non-specific. [5] [6] [7] The onset of symptoms is usually shortly (within a few hours) after specific food or drink consumption, and subsequent remission usually happens in 4-8 weeks of dieting, [8] that is excluding food that causes the onset of symptoms.
"Your blood pressure is supposed to be under 140 over 90, optimally closer to 120 over 80."
When blood pressure falls many physiological cascades commence in order to return the blood pressure to a more appropriate level. The blood pressure fall is detected by a decrease in blood flow and thus a decrease in glomerular filtration rate (GFR). Decrease in GFR is sensed as a decrease in Na + levels by the macula densa.
Since human blood is slightly basic (with a normal pH range of 7.35 to 7.45) therefore the predominant form of histamine present in human blood is monoprotic at the aliphatic nitrogen. Histamine is a monoamine neurotransmitter .
A hypertensive emergency is not based solely on an absolute level of blood pressure, but also on a patient's baseline blood pressure before the hypertensive crisis occurs. Individuals with a history of chronic hypertension may not tolerate a "normal" blood pressure, and can therefore present symptomatically with hypotension , including fatigue ...
Using the results of the blood pressure test, the health care provider will diagnose prehypertension or high blood pressure if: For an adult, systolic or diastolic readings are consistently higher than 120/80 mmHg. A child's blood pressure numbers are outside average numbers for children of the same age, gender, and height. [40]
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