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In genetics, the coefficient of coincidence (c.o.c.) is a measure of interference in the formation of chromosomal crossovers during meiosis. It is generally the case that, if there is a crossover at one spot on a chromosome, this decreases the likelihood of a crossover in a nearby spot. [1] This is called interference.
Crossover interference is the term used to refer to the non-random placement of crossovers with respect to each other during meiosis.The term is attributed to Hermann Joseph Muller, who observed that one crossover "interferes with the coincident occurrence of another crossing over in the same pair of chromosomes, and I have accordingly termed this phenomenon ‘interference’."
The Kosambi mapping function was introduced to account for the impact played by crossover interference on recombination frequency. It introduces a parameter C, representing the coefficient of coincidence, and sets it equal to 2r. For loci which are strongly linked, interference is strong; otherwise, interference decreases towards zero. [5]
There are two popular and overlapping theories that explain the origins of crossing-over, coming from the different theories on the origin of meiosis.The first theory rests upon the idea that meiosis evolved as another method of DNA repair, and thus crossing-over is a novel way to replace possibly damaged sections of DNA. [9]
A Washington, D.C. man has been arrested for threatening flight attendants on a United Airlines plane traveling from Houston to New Jersey. Kedus Yacob Damtew, 38, was charged with one count of ...
Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction.Two genetic markers that are physically near to each other are unlikely to be separated onto different chromatids during chromosomal crossover, and are therefore said to be more linked than markers that are far apart.
Gen Zers said they planned to spend about 21% more than last year for the holidays, according to the report's survey of 1,000 U.S. consumers. In contrast, researchers found millennials – born ...
Former Google CEO Eric Schmidt says human-directed AI-controlled drones are the future of war. Schmidt's startup, White Stork, is developing drones for Ukraine to use in its war with Russia.