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Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
By 2006, an extensive body of work from several independent studies, including studies from yeast to mammals, all pointed to rapamycin as having an anti-aging effect or at least slowing down the ...
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
Chemical structure of rapamycin, a pharmaceutical under evaluation for its effects on longevity. The project engages the general public to register their dogs in the studies, and therefore the project is an example of citizen science. [3] As of 2022 nearly 40,000 dogs have been registered with the project. [1]
As with many supplements, there is a possible risk of mild side effects, especially in high doses. These include stomach upset, headache, or skin flushing. NAD injections may cause temporary ...
Rapamycin is a drug primarily used to prevent organ transplant rejection. Kaeberlein said it can increase the life of a mouse by 30 percent – though scientists aren't sure why. "It's a three ...
Side effects in dogs and cats include hypersalivation, diarrhea, loss of appetite, and vomiting. [11] [15] Eight percent of dogs taking maropitant at doses meant to prevent motion sickness vomited right after, likely due to the local effects maropitant had on the gastrointestinal tract. Small amounts of food beforehand can prevent such post ...
The dog then causes further trauma to the skin by itching and rubbing at the area, leading to a secondary bacterial infection." Acute moist dermatitis: Symptoms A patch of moist, inflamed skin ...
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