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  2. Acute limb ischaemia - Wikipedia

    en.wikipedia.org/wiki/Acute_limb_ischaemia

    Acute limb ischaemia (ALI) occurs when there is a sudden lack of blood flow to a limb [1] within 14 days of symptoms onset. [2] On the other hand, when the symptoms exceed 14 days, [ 3 ] it is called critical limb ischemia (CLI).

  3. Chronic limb threatening ischemia - Wikipedia

    en.wikipedia.org/wiki/Chronic_limb_threatening...

    Critical limb ischemia is different from acute limb ischemia. Acute limb ischemia is a sudden lack of blood flow to the limb, for example caused by an embolus whereas critical limb ischemia is a late sign of a progressive chronic disease.

  4. Ischemia - Wikipedia

    en.wikipedia.org/wiki/Ischemia

    Brain ischemia is insufficient blood flow to the brain, and can be acute or chronic. Acute ischemic stroke is a neurological emergency typically caused by a blood clot blocking blood flow in a vessel in the brain. [15] Chronic ischemia of the brain may result in a form of dementia called vascular dementia. [16]

  5. Arterial occlusion - Wikipedia

    en.wikipedia.org/wiki/Arterial_occlusion

    Peripheral artery disease (PAD), or limb ischemia, affects the femoral, popliteal, or iliac arteries. [17] PAD is caused by atherosclerotic plaques that occlude blood flow to extremities. [ 5 ] Once blood flow is impeded, ischemic muscle cells switch from aerobic to anaerobic metabolism to cope with oxygen scarcity.

  6. Peripheral artery disease - Wikipedia

    en.wikipedia.org/wiki/Peripheral_artery_disease

    Critical limb ischemia occurs when the obstruction of blood flow in the artery is compromised to the point where the blood is unable to maintain oxygenation of the tissue at rest. [19] This can lead to pain at rest, a feeling of coldness, or numbness in the affected foot and toes. Other complications of severe PAD include lower limb tissue loss ...

  7. Compartment syndrome - Wikipedia

    en.wikipedia.org/wiki/Compartment_syndrome

    Symptoms of acute compartment syndrome (ACS) can include severe pain, poor pulses, decreased ability to move, numbness, or a pale color of the affected limb. [5] It is most commonly due to physical trauma such as a bone fracture (up to 75% of cases) or crush injury , but it can also be caused by acute exertion during sport.

  8. Reperfusion injury - Wikipedia

    en.wikipedia.org/wiki/Reperfusion_injury

    The main reason for the acute phase of ischemia-reperfusion injury is oxygen deprivation and, therefore, arrest of generation of ATP (cellular energy currency) by mitochondria oxidative phosphorylation. Tissue damage due to the general energy deficit during ischemia is followed by reperfusion (increase of oxygen level) when the injury is enhanced.

  9. Limb infarction - Wikipedia

    en.wikipedia.org/wiki/Limb_infarction

    The major tissues affected are nerves and muscles, where irreversible damage starts to occur after 4–6 hours of cessation of blood supply. [4] Skeletal muscle, the major tissue affected, is still relatively resistant to infarction compared to the heart and brain because its ability to rely on anaerobic metabolism by glycogen stored in the cells may supply the muscle tissue long enough for ...