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2. List of antineoplastic agents - Wikipedia

   en.wikipedia.org/wiki/List_of_antineoplastic_agents

   Refractory metastatic melanoma, childhood acute lymphoblastic leukaemia, chronic myeloid leukaemia in blast crises, neuroblastoma, non-small cell lung cancer and breast cancer. Myelosuppression, neurotoxicity and paralytic ileus. Vinflunine: IV: As above. Bladder cancer: As per vinblastine. Vinorelbine: IV: As above. Breast cancer and non-small ...

3. List of drugs granted breakthrough therapy designation

   en.wikipedia.org/wiki/List_of_drugs_granted...

   advanced unresectable or metastatic HER2-positive breast cancer: Pemigatinib: Incyte Corp: metastatic cholangiocarcinoma with FGFR2 fusion Sacituzumab govitecan: Immunomedics: metastatic triple-negative breast cancer: Capmatinib: Novartis: metastatic non-small cell lung cancer: Selpercatinib: Loxo Oncology: metastatic RET fusion-positive non ...

4. Breast cancer management - Wikipedia

   en.wikipedia.org/wiki/Breast_cancer_management

   Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.

5. Trastuzumab - Wikipedia

   en.wikipedia.org/wiki/Trastuzumab

   In November 2017, the European Commission authorized Ontruzant, a biosimilar from Samsung Bioepis Co., Ltd, for the treatment of early breast cancer, metastatic breast cancer and metastatic gastric cancer. [16] [17] Ontruzant is the first trastuzumab biosimilar to receive regulatory approval in the European Union. [91]

6. Metastatic breast cancer - Wikipedia

   en.wikipedia.org/wiki/Metastatic_breast_cancer

   Common sites of metastasis for breast cancer. Metastatic breast cancer, also referred to as metastases, advanced breast cancer, secondary tumors, secondaries or stage IV breast cancer, is a stage of breast cancer where the breast cancer cells have spread to distant sites beyond the axillary lymph nodes. There is no cure for metastatic breast ...

7. Trastuzumab emtansine - Wikipedia

   en.wikipedia.org/wiki/Trastuzumab_emtansine

   First line treatment for metastatic breast cancer: the MARIANNE study [33] compares taxane (docetaxel or paclitaxel) plus trastuzumab vs T-DM1 vs T-DM1 plus pertuzumab as first-line treatment for people with HER2 positive unresectable locally advanced or metastatic breast cancer; On 19 December 2014, Roche reported the results of the MARIANNE ...