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Cholestatic pruritus is the sensation of itch due to nearly any liver disease, but the most commonly associated entities are primary biliary cholangitis, primary sclerosing cholangitis, obstructive choledocholithiasis, carcinoma of the bile duct, cholestasis (also see drug-induced pruritus), and chronic hepatitis C viral infection and other forms of viral hepatitis.
[5] [6] Maralixibat chloride is an ileal bile acid transporter (IBAT) inhibitor. [5] The most common side effects include diarrhea and abdominal pain (belly ache). [6] Maralixibat chloride was approved for medical use in the United States in September 2021, [5] [7] [8] [9] and in the European Union in December 2022. [6]
It has also been called bile acid-induced diarrhea, cholerheic or choleretic enteropathy, bile salt diarrhea or bile salt malabsorption. It can result from malabsorption secondary to gastrointestinal disease, or be a primary disorder, associated with excessive bile acid production. Treatment with bile acid sequestrants is often effective ...
Chronic diarrhea may be caused by excess bile salts entering the colon rather than being absorbed at the end of the small intestine (the ileum). This condition of bile acid malabsorption occurs after surgery to the ileum , in Crohn's disease , with a number of other gastrointestinal causes, or is commonly a primary, idiopathic condition.
Colestyramine or cholestyramine (trade names Questran, Questran Light, Cholybar, Olestyr) is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption. It is a strong ion exchange resin , which means it can exchange its chloride anions with anionic bile acids in the gastrointestinal tract and bind them ...
Excess fat can be a problem because the bile salts your body uses to digest them can irritate the skin around your anus, says Brooks D. Cash, M.D., a professor of medicine at the University of ...
“Signs that scalp scabs may be related to an infection or underlying health condition include persistent itch, redness, pus, hair loss, or lack of response to over-the-counter treatments ...
Ursodeoxycholic acid (UDCA), also known as ursodiol, is a secondary bile acid, produced in humans and most other species from metabolism by intestinal bacteria.It is synthesized in the liver in some species, and was first identified in bile of bears of genus Ursus, from which its name derived. [8]