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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic index. For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug ...
In pharmacology, clearance is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [ 1 ] The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time.
Due to the high level of incorrect calculation errors, alternative pediatric emergency tapes Archived 2019-01-20 at the Wayback Machine that can be customized have gained popularity. A tenfold adult overdose of a standard adult medication would require multiple syringes and tends, therefore, to be obvious to a caregiver, effectively warning of ...
take (often effectively a noun meaning "prescription"—medical prescription or prescription drug) rep. repetatur: let it be repeated s. signa: write (write on the label) s.a. secundum artem: according to the art (accepted practice or best practice) SC subcutaneous "SC" can be mistaken for "SL," meaning sublingual. See also SQ: sem. semen seed
An advanced emergency medical technician (AEMT) is a provider of emergency medical services in the United States. A transition to this level of training from the emergency medical technician-intermediate, which have somewhat less training, [1] began in 2013 and has been implemented by most states [citation needed]. AEMTs are not intended to ...
Using NHTSA guidelines, the National Registry of Emergency Medical Technicians have developed and implemented certification tests for the NHTSA EMT levels, including the EMT level. [2] As of 2006, 39 US states utilize the NREMT EMT exam as part of the state licensing and/or certification procedure. [3]
Routes of administration are usually classified by application location (or exposition). The route or course the active substance takes from application location to the location where it has its target effect is usually rather a matter of pharmacokinetics (concerning the processes of uptake, distribution, and elimination of drugs).
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