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Treatment of acquired angioedema is separated into two main parts. First controlling acute symptoms during angioedema attacks is crucial for preventing and lowering the risk of mortality. [20] Second, managing AAE chronically with prophylactic treatment is important to improve prognosis and quality of life. [20]
Treatment to protect the airway may include intubation or cricothyroidotomy. [1] Histamine-related angioedema can be treated with antihistamines, corticosteroids, and epinephrine. [1] In those with bradykinin-related disease a C1 esterase inhibitor, ecallantide, or icatibant may be used. [1] Fresh frozen plasma may be used instead. [1]
Ecallantide (trade name Kalbitor) is a drug used for the treatment of hereditary angioedema (HAE) and in the prevention of blood loss in cardiothoracic surgery. [2] It is an inhibitor of the protein kallikrein and a 60-amino acid polypeptide which was developed from a Kunitz domain through phage display to mimic antibodies inhibiting kallikrein.
Hereditary angioedema with normal C1-inhibitor is a genetically heterogeneous disorder. Several molecular subtypes have been identified. A first subtype, identified in 2006, is caused by mutations of the F12 gene encoding coagulation factor XII (also known as Hageman factor).
Angioedema; Diarrhea; Pruritus (atopic dermatitis, insect bites) Anaphylactic or anaphylactoid reactions—adjunct only; Nausea and vomiting; Sedation (first-generation H 1-antihistamines) H 1-antihistamines can be administered topically (through the skin, nose, or eyes) or systemically, based on the nature of the allergic condition.
Icatibant received orphan drug status in Australia, the EU, Switzerland, and the US for the treatment of hereditary angioedema (HAE). [7]In the EU, the approval by the European Commission (July 2008) allows Jerini to market Firazyr in the European Union's 27 member states, as well as Switzerland, Liechtenstein and Iceland, making it the first product to be approved in all EU countries for the ...
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