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Endochondral ossification is responsible for development of most bones including long and short bones, [4] the bones of the axial (ribs and vertebrae) and the appendicular skeleton (e.g. upper and lower limbs), [5] the bones of the skull base (including the ethmoid and sphenoid bones) [6] and the medial end of the clavicle. [7]
The process of endochondral ossification, which converts the cartilage models into bone, begins by the twelfth week of embryonic development. At birth, ossification of much of the bone has occurred, but the hyaline cartilage of the epiphyseal plate will remain throughout childhood and adolescence to allow for bone lengthening.
Diagram showing stages of endochondral ossification. Endochondral ossification is the formation of long bones and other bones. This requires a hyaline cartilage precursor. There are two centers of ossification for endochondral ossification. The primary center. In long bones, bone tissue first appears in the diaphysis (middle of shaft).
For endochondral ossification, deposition of bone only occurs after the mineralised cartilage. [ citation needed ] This process of healing occurs when the fracture is treated conservatively using orthopaedic cast or immobilisation, external fixation , or internal fixation .
Skeletal animation or rigging is a technique in computer animation in which a character (or other articulated object) is represented in two parts: a polygonal or parametric mesh representation of the surface of the object, and a hierarchical set of interconnected parts (called joints or bones, and collectively forming the skeleton), a virtual ...
The longitudinal growth of long bones is a result of endochondral ossification at the epiphyseal plate. Bone growth in length is stimulated by the production of growth hormone (GH), a secretion of the anterior lobe of the pituitary gland .
An ossification center is a point where ossification of the hyaline cartilage begins. The first step in ossification is that the chondrocytes at this point become hypertrophic and arrange themselves in rows. [1] The matrix in which they are imbedded increases in quantity, so that the cells become further separated from each other.
The skull is a complex structure; its bones are formed both by intramembranous and endochondral ossification. The skull roof bones, comprising the bones of the facial skeleton and the sides and roof of the neurocranium, are dermal bones formed by intramembranous ossification, though the temporal bones are formed by endochondral ossification.