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1942 – gramicidin S, the first peptide antibiotic; 1942 – sulfadimidine; 1943 – sulfamerazine; 1944 – streptomycin, the first aminoglycoside [2] 1947 – sulfadiazine; 1948 – chlortetracycline, the first tetracycline; 1949 – chloramphenicol, the first amphenicol [2] 1949 – neomycin; 1950 – oxytetracycline; 1950 – penicillin G ...
The history of penicillin follows observations and discoveries of evidence of antibiotic activity of the mould Penicillium that led to the development of penicillins that became the first widely used antibiotics. Following the production of a relatively pure compound in 1942, penicillin was the first naturally-derived antibiotic.
Penicillin ushered in the antibiotics revolution, with amazing results during war and peace. Science & Society Picture Library/SSPL via Getty ImagesAlbert Alexander was dying. World War II was ...
Modern antibiotics are tested using a method similar to Fleming's discovery. Fleming also discovered very early that bacteria developed antibiotic resistance whenever too little penicillin was used or when it was used for too short a period. Almroth Wright had predicted antibiotic resistance even before it was noticed during experiments.
Ernest Duchesne (30 May 1874 – 12 April 1912) was a French physician who noted that certain molds kill bacteria.He made this discovery 32 years before Alexander Fleming discovered the antibiotic properties of penicillin, a substance derived from those molds, but his research went unnoticed.
The magic bullet is a scientific concept developed by the German Nobel laureate Paul Ehrlich in 1907. [1] While working at the Institute of Experimental Therapy (Institut für experimentelle Therapie), Ehrlich formed an idea that it could be possible to kill specific microbes (such as bacteria), which cause diseases in the body, without harming the body itself.
Because of this inhibition the antibiotics are most effective when the bacteria are in the logarithmic phase of growth, where then they are synthesizing the cell wall. If the bacteria are in the stationary phase of growth, then there is no wall synthesizing in progress, and the antibiotics have much lower effect. [3]
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