Search results
Results from the WOW.Com Content Network
N,N-Dimethyltryptamine (DMT or N,N-DMT) is a substituted tryptamine that occurs in many plants and animals, including humans, and which is both a derivative and a structural analog of tryptamine. [1] [2] [3] DMT is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen. [9]
6-MeO-DMT, or 6-methoxy-N,N-dimethyltryptamine, also known as 6-OMe-DMT, is a serotonergic drug of the tryptamine family. [ 1 ] [ 2 ] It is the 6- methoxy derivative of the serotonergic psychedelic N , N -dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT .
Strassman has conjectured that when a person is approaching death or possibly when in a dream state, the body releases a relatively large amount of DMT, mediating some of the imagery survivors of near-death experiences report. But there are no data correlating endogenous DMT activity to non-drug-related altered states of consciousness. [16]
The metabolism of 5-MeO-DMT can be dramatically reduced and its levels markedly augmented and prolonged by monoamine oxidase inhibitors (MAOIs). [2] In addition, MAOIs allow 5-MeO-DMT to become orally active in humans. [2] Combination of 5-MeO-DMT with MAOIs has sometimes resulted in serotonin syndrome and death in humans. [2]
DMT occurs naturally in the human body and is speculated to be released at the time of death, but it is normally digested in the stomach if consumed and an MAOI (monoamine oxidase inhibitor), in this case tetrahydroharmine, harmine and harmaline, is needed to allow it to reach the brain in this way, thus the use of the vine. The Santo Daime ...
The drug does not produce hallucinogen-like stimulus generalization in animal drug discrimination tests and similarly does not produce the head-twitch response, an animal behavioral proxy of psychedelic-like effects.
Psilocin, also known as 4-hydroxy-N,N-dimethyltryptamine (4-OH-DMT), is a substituted tryptamine alkaloid and a serotonergic psychedelic. It is present in most psychedelic mushrooms [ 7 ] together with its phosphorylated counterpart psilocybin .
Although the Chidester story has been given continued exposure by US media, there has not been anywhere else, either before or since this controversial incident, any other reported cases involving or alleging Salvia divinorum as a serious factor in suicide, overdose, accidental, or any other kind of death.