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Signs of hyperestrogenism may include heightened levels of one or more of the estrogen sex hormones (usually estradiol and/or estrone), lowered levels of follicle-stimulating hormone and/or luteinizing hormone (due to suppression of the hypothalamic–pituitary–gonadal axis by estrogen), and lowered levels of androgens such as testosterone (generally only relevant to males). [1]
Aromatase excess syndrome (AES or AEXS) is a rarely diagnosed genetic and endocrine syndrome which is characterized by an overexpression of aromatase, the enzyme responsible for the biosynthesis of the estrogen sex hormones from the androgens, in turn resulting in excessive levels of circulating estrogens and, accordingly, symptoms of hyperestrogenism.
The American Board of Cosmetic Surgery reports surgery is the "most effective known treatment for gynecomastia." [64] Surgical treatment should be considered if the gynecomastia persists for more than 12 months, causes distress (i.e. physical discomfort or psychological distress), and is in the fibrotic stage. [65]
Just like you, the female sex hormone is responsible for a lot.
The application of estrogen on medicine can be divided into a number of aspects. The best known ones are breast cancer and coronary heart disease. Estrogen also plays very important role in animal metabolism balance. These unexpected diseases hindered estrogen to get involved in neurodegenerative disease therapy.
Estrogen, at some concentration, has been found to be essential for male fertility/spermatogenesis. [65] [66] However, estrogen levels that are too high can impair male fertility by suppressing gonadotropin secretion and thereby diminishing intratesticular androgen levels. [60]
An estrogen-dependent condition can be that relating to the differentiation in the steroid sex hormone that is associated with the female reproductive system and sex characteristics. [1] These conditions can fall under the umbrella of hypoestrogenism, hyperestrogenim, or any sensitivity to the presence of estrogen in the body.
High-dose estrogen therapy (HDE) is a type of hormone therapy in which high doses of estrogens are given. [1] When given in combination with a high dose of progestogen , it has been referred to as pseudopregnancy .