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Sirtex Medical Limited is a medical device firm that offers radioactive treatment for inoperable liver cancer called SIR-Spheres microspheres. [1] Sirtex was founded in 1997 in Australia and today has offices and production facilities in the U.S. , Australia , Germany , and Singapore .
SIR-Spheres microspheres are used to treat patients with unresectable liver cancer. These are mostly patients with hepatocellular carcinoma (HCC), metastatic colorectal cancer (mCRC), or metastatic neuroendocrine tumours (mNET). [1] Therapy goals are local disease control, downstaging to resection, bridging to transplantation, and extended ...
SIR-Spheres were CE-marked as a medical device in 2002, for treating advanced inoperable liver tumors, and Theraspheres in 2014, for treating hepatic neoplasia. [37] QuiremSpheres (PLLA 166 Ho microspheres) received their CE mark in April 2015 for treating unresectable liver tumors and are currently only available for the European market. [37] [41]
TheraSphere is a radiotherapy treatment for hepatocellular carcinoma (HCC) that consists of millions of microscopic, radioactive glass microspheres (20–30 micrometres in diameter) being infused into the arteries that feed liver tumors.
Iodine-131 (131 I) is the most common RNT worldwide and uses the simple compound sodium iodide with a radioactive isotope of iodine.The patient (human or animal) may ingest an oral solid or liquid amount or receive an intravenous injection of a solution of the compound.
Yttrium-90 is produced by the nuclear decay of strontium-90 which has a half-life of nearly 29 years and is a fission product of uranium used in nuclear reactors. As the strontium-90 decays, chemical high-purity separation is used to isolate the yttrium-90 before precipitation.
Intraoperative electron radiation therapy is the application of electron radiation directly to the residual tumor or tumor bed during cancer surgery. [1] [2] Electron beams are useful for intraoperative radiation treatment because, depending on the electron energy, the dose falls off rapidly behind the target site, therefore sparing underlying healthy tissue.
The device consists of a small linear accelerator attached to a robotic arm, along with an integrated image guidance system. During treatment, the image guidance system captures 3D images, tracks the movement of tumors, and guides the robotic arm to accurately aim the treatment beam at the moving tumor.