Search results
Results from the WOW.Com Content Network
The remaining copy of the tumor suppressor gene can be inactivated by a point mutation or via other mechanisms, resulting in a loss of heterozygosity event, and leaving no tumor suppressor gene to protect the body. Loss of heterozygosity does not imply a homozygous state (which would require the presence of two identical alleles in the cell).
One can modify this definition and consider a grouping per sub-population instead of per individual. Population geneticists have used that idea to measure the degree of structure in a population. Unfortunately, there is a large number of definitions for , causing some confusion in the scientific literature. A common definition is the following:
This resistance to infection is the main reason the SCA allele and SCA disease still exist. It is found in greatest frequency in populations where malaria was and often still is a serious problem. Approximately one in 10 African Americans is a carrier, [15] as their recent ancestry is from malaria-stricken regions. Other populations in Africa ...
Heterozygosity values of 51 worldwide human populations. [10] Sub-Saharan Africans have the highest values in the world. In population genetics, the concept of heterozygosity is commonly extended to refer to the population as a whole, i.e., the fraction of individuals in a population that are heterozygous for a particular locus. It can also ...
Another mechanism responsible for inbreeding depression is the fitness advantage of heterozygosity, which is known as overdominance. This can lead to reduced fitness of a population with many homozygous genotypes, even if they are not deleterious or recessive.
Heterozygosity is the fraction of individuals in a population that are heterozygous for a particular locus. Alleles per locus is also used to demonstrate variability. Nucleotide diversity is the extent of nucleotide polymorphisms within a population, and is commonly measured through molecular markers such as micro- and minisatellite sequences ...
Another derived definition of f for the full Distribution is that f also equals the rise in homozygosity, which equals the fall in heterozygosity. [33] For the example, these frequency changes are 0.1069 and 0.1070, respectively. This result is different to the above, indicating that bias with respect to the full underlying distribution is ...
[1] [2] The term is generally used to mean the chance or ability of a population to avoid the problems of inbreeding. [1] Less commonly genetic viability can also be used in respect to a single cell or on an individual level. [1] Inbreeding depletes heterozygosity of the genome, meaning there is a greater chance of identical alleles at a locus. [1]