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  2. Melatonin as a medication and supplement - Wikipedia

    en.wikipedia.org/wiki/Melatonin_as_a_medication...

    It is thought to activate these receptors in the suprachiasmatic nucleus of the hypothalamus in the brain to regulate the circadian clock and sleep–wake cycles. [21] Immediate-release melatonin has a short elimination half-life of about 20 to 50 minutes. [22] [9] [10] Prolonged-release melatonin used as a medication has a half-life of 3.5 to ...

  3. Delayed sleep phase disorder - Wikipedia

    en.wikipedia.org/wiki/Delayed_sleep_phase_disorder

    Side effects of melatonin may include sleep disturbance, nightmares, daytime sleepiness, and depression, though the current tendency to use lower doses has decreased such complaints. Large doses of melatonin can even be counterproductive: Lewy et al. [ 48 ] provide support to "the idea that too much melatonin may spill over onto the wrong zone ...

  4. Ramelteon - Wikipedia

    en.wikipedia.org/wiki/Ramelteon

    Ramelteon, sold under the brand name Rozerem among others, is a melatonin agonist medication which is used in the treatment of insomnia. [3] [5] It is indicated specifically for the treatment of insomnia characterized by difficulties with sleep onset. [3]

  5. Is melatonin or ashwagandha better for sleep? Experts weigh in

    www.aol.com/finance/melatonin-ashwagandha-better...

    While melatonin is said to promote sleep, ashwagandha is known to help reduce stress for an easier night’s sleep. ... he recommends a sustained release of a higher dose of melatonin. To reap the ...

  6. Insomnia - Wikipedia

    en.wikipedia.org/wiki/Insomnia

    Prolonged-release melatonin may improve quality of sleep in older people with minimal side effects. [ 166 ] [ 167 ] Studies have also shown that children who are on the autism spectrum or have learning disabilities, attention-deficit hyperactivity disorder (ADHD) or related neurological diseases can benefit from the use of melatonin.

  7. Daridorexant - Wikipedia

    en.wikipedia.org/wiki/Daridorexant

    Network meta-analyses have assessed the sleep-promoting effects of orexin receptor antagonists and have compared them between one another as well as to other sleep aids including benzodiazepines, Z-drugs, antihistamines, sedative antidepressants (e.g., trazodone, doxepin, amitriptyline, mirtazapine), and melatonin receptor agonists.

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