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  2. Relationship between telomeres and longevity - Wikipedia

    en.wikipedia.org/wiki/Relationship_between...

    Telomeres at the end of a chromosome. The relationship between telomeres and longevity and changing the length of telomeres is one of the new fields of research on increasing human lifespan and even human immortality. [1] [2] Telomeres are sequences at the ends of chromosomes that shorten with each cell division and determine the lifespan of ...

  3. Telomere - Wikipedia

    en.wikipedia.org/wiki/Telomere

    A telomere (/ ˈ t ɛ l ə m ɪər, ˈ t iː l ə-/; from Ancient Greek τέλος (télos) 'end' and μέρος (méros) 'part') is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes (see Sequences). Telomeres are a widespread genetic feature most commonly found in eukaryotes.

  4. Telomeres in the cell cycle - Wikipedia

    en.wikipedia.org/wiki/Telomeres_in_the_cell_cycle

    They then used α factor to block cells with induced short telomeres in late G1 phase and measured the change in telomere length when the cells were released under a variety of conditions. They found that when the cells were released and concurrently treated with nocodazole , a G2/M phase cell cycle inhibitor, telomere length increased for the ...

  5. Biological immortality - Wikipedia

    en.wikipedia.org/wiki/Biological_immortality

    The term "immortalization" was first applied to cancer cells that expressed the telomere-lengthening enzyme telomerase, and thereby avoided apoptosis—i.e. cell death caused by intracellular mechanisms.

  6. Cellular senescence - Wikipedia

    en.wikipedia.org/wiki/Cellular_senescence

    As the cell divides, the telomeres on the end of a linear chromosome get shorter. The telomeres will eventually no longer be present on the chromosome. This end stage is the concept that links the deterioration of telomeres to aging. Top: Primary mouse embryonic fibroblast cells (MEFs) before senescence. Spindle-shaped.

  7. Telomerase - Wikipedia

    en.wikipedia.org/wiki/Telomerase

    Telomerase, also called terminal transferase, [1] is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each end of the chromosomes of most eukaryotes .

  8. Evolution of ageing - Wikipedia

    en.wikipedia.org/wiki/Evolution_of_ageing

    Telomeres are recurring nucleotide sequences that protect the ends of our chromosome; they are sensitive to oxidative stress and degrade during chromosomal replication. Telomerase is a ribonucleotide protein that helps repair and replace degraded telomeres. However, telomerase fails us as we age; it becomes less able to repair telomeres, and ...

  9. Hallmarks of aging - Wikipedia

    en.wikipedia.org/wiki/Hallmarks_of_aging

    Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death.