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Norgestrel, sold under the brand name Opill among others, is a progestin which is used in birth control pills. It is often combined with the estrogen ethinylestradiol , marketed as Ovral. It is also used in menopausal hormone therapy .
Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins. [7] [8] In the past, EE was widely used for various indications such as the treatment of menopausal symptoms, gynecological disorders, and certain hormone-sensitive cancers.
Norgestimate, sold under the brand name Ortho Tri-Cyclen among others, is a progestin medication which is used in birth control pills for women and in menopausal hormone therapy. [ 1 ] [ 3 ] [ 4 ] [ 5 ] The medication is available in combination with an estrogen and is not available alone. [ 6 ]
Estradiol valerate and cyproterone acetate (brand name Femilar) – introduced in Finland (only) in 1993 [3] Estradiol valerate and dienogest (brand names Qlaira, Natazia) – introduced in Europe in 2009 and the U.S. Tooltip United States in 2010 [4] Estradiol and nomegestrol acetate (brand name Zoely) – introduced in Europe in 2011 [5]
Opill has been FDA approved since 1973, but this would mark the first time a birth control pill would be available without a prescription in the U.S.
Norelgestromin is available only as a transdermal contraceptive patch in combination with ethinyl estradiol. [6] The Ortho Evra patch is a 20 cm 2, once-weekly adhesive that contains 6.0 mg norelgestromin and 0.6 mg ethinyl estradiol and delivers 200 μg/day norelgestromin and 35 μg/day ethinyl estradiol.
The risk of venous thromboembolism with EE/CPA-containing birth control pills is similar to that with EE and gestodene-, desogestrel-, and drospirenone-containing birth control pills and about 50 to 80% higher than with EE and levonorgestrel-containing birth control pills.
Norethindrone acetate and ethinyl estradiol have been approved in the US for the prevention of pregnancy as a swallowable tablet since 1968. [5] In 2022, the combination of ethinylestradiol with norethisterone or with norethisterone acetate was the 80th most commonly prescribed medication in the United States, with more than 8 million ...