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Still, another form of illness called chronic refractory cough doesn’t respond to treatment. It involves cough nerves that are hypersensitive to triggers that don’t make others cough, such as ...
The health regulator concluded the company's application for the drug, gefapixant, did not meet substantial evidence of effectiveness for treating refractory chronic cough and unexplained chronic ...
If approved, Merck's drug is up against GSK-owned camlipixant, which is in late-stage development for the treatment of chronic cough with anticipated regulatory approval and launch in 2026.
The prevalence of chronic cough in many communities in Europe and the U.S. is 9–33% of the population. Chronic cough is three times more common in those who smoke compared to people who never smoke. [1] The most important risk factors for chronic cough are tobacco smoking and working in a dusty job. [30]
Gefapixant, sold under the brand name Lyfnua, is a medication used to treat chronic (long-term) cough. [1] It acts as an antagonist of the P2RX3 receptor. [2] [3] [4] It was approved for medical use in the European Union in September 2023. [1]
Treatment options depend on the nature of an individual's post-nasal drip and its cause. Antibiotics may be prescribed if the PND is the result of bacterial sinusitis. [ 8 ] In cases where PND is caused by allergic rhinitis or irritant rhinitis, avoidance of allergens or irritating factors such as dander, cigarette smoke, and cleaning supplies ...
Merck's (MRK) two phase III studies on gefapixant (MK-7264) for the treatment of refractory or unexplained chronic cough meet the primary efficacy endpoints.
A postinfectious cough is a lingering cough that follows a respiratory tract infection, such as a common cold or flu and lasting up to eight weeks. Postinfectious cough is a clinically recognized condition represented within the medical literature.
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