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3. Reduces the Risk of Cardiovascular Events. Metformin also may have some benefits for your heart, possibly helping to reduce the risk of developing cardiovascular disease and heart failure.
Because metformin decreases liver uptake of lactate, any condition that may precipitate lactic acidosis is a contraindication. Common causes include alcoholism (due to depletion of NAD+ stores), heart failure, and respiratory disease (due to inadequate tissue oxygenation); the most common cause is kidney disease. [95]
Sotagliflozin (Inpefa) is a dual SGLT1/SGLT2 inhibitor approved by the US Food and Drug Administration (FDA) in May 2023, to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure or type 2 diabetes, chronic kidney disease, and other cardiovascular risk factors ...
Most hospitalized older persons do not meet the enrollment criteria of clinical trials in heart failure. Am Heart J 2003;146:250-257. PMID 12891192; Masoudi FA, Wang Y, Inzucchi SI, Havranek EP, Setaro JF, Krumholz HF. Metformin and thiazolidinedione use in Medicare patients with heart failure. JAMA 2003;290:81-85. PMID 12837715
A smaller study on metformin also found that the average weight lost in 154 patients was between 5.6 and 7 kilograms — or 13 to 15 ... high cholesterol, heart disease, heart attacks, and more.
Typical reduction in glycated hemoglobin (A1C) values for Metformin is 1.5–2.0% Metformin (Glucophage) may be the best choice for patients who also have heart failure, [10] but it should be temporarily discontinued before any radiographic procedure involving intravenous iodinated contrast, as patients are at an increased risk of lactic acidosis.
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