Search results
Results from the WOW.Com Content Network
Reaction of the lactam-derived enol phosphates 4 of 2,5-diketopiperazines with palladium catalyzed reactions (reduction, Suzuki and Stille cross-coupling reactions) enables the synthesis of a range of functionalised 1,4-dihydropyrazines 5 which can be aromatized to 1,4-pyrazines 6 in the presence of acid.
Piperazine is freely soluble in water and ethylene glycol, but insoluble in diethyl ether. It is a weak base with two pK b of 5.35 and 9.73 at 25 °C.; the pH of a 10% aqueous solution of piperazine is 10.8–11.8. Piperazine readily absorbs water and carbon dioxide from the air.
A diketopiperazine (DKP), also known as a dioxopiperazine or piperazinedione, is a class of organic compounds related to piperazine but containing two amide linkages. DKP's are the smallest known class of cyclic peptide. [1] Despite their name, they are not ketones, but amides.
It is both a precursor in the synthesis of aripiprazole and one of its metabolites. [ 1 ] [ 2 ] It is unclear whether 2,3-DCPP is pharmacologically active as a serotonin receptor agonist similar to its close analogue 3-chlorophenylpiperazine ( m CPP), though it has been shown to act as a partial agonist of the dopamine D 2 and D 3 receptors.
N-Methylpiperazine is a common building block used in organic synthesis. [2] For example, N-methylpiperazine is used in the manufacture of various pharmaceutical drugs including cyclizine, [3] meclizine, and sildenafil. The lithium salt, lithium N-methylpiperazide, is used as a reagent in organic synthesis for protection of aryl aldehydes. [4]
In the Staedel–Rugheimer pyrazine synthesis (1876), 2-chloroacetophenone is reacted with ammonia to the amino ketone, then condensed and then oxidized to a pyrazine. [5] A variation is the Gutknecht pyrazine synthesis (1879) also based on this selfcondensation , but differing in the way the alpha-ketoamine is synthesised.
1-(1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non- selective , mixed serotonergic agent, exerting partial agonism at the 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , and 5-HT 1F receptors , [ 1 ] [ 2 ] [ 3 ] while antagonizing the 5-HT 2A , 5-HT 2B , and 5-HT 2C receptors .
Terazosin synthesis: [6] Reaction of piperazine with 2-furoyl chloride followed by catalytic hydrogenation of the furan ring leads to 2. This, when heated in the presence of 2-chloro-6,7-dimethoxyquinazolin-4-amine (1) undergoes direct alkylation to terazosin (3).